We Believe All Men Have a Right to Know
Pints for Prostates believes guys should know their numbers so they can make informed decisions about their health. That's why we have always advocated for men to talk with their health care providers about testing options and to get a baseline PSA (Prostate Specific Antigen) test at age 40.
At a number of our events we partner with the Prostate Conditions Education Council to provide free men's health screenings. In 2017, more than 700 men took advantage of this opportunity and received not only their PSA numbers, but also cholesterol, glucose and testosterone levels. This confidential health data is mailed to the about a week after the event, along with information on what the numbers mean so they can have follow up discussions with health care providers.
Men are often reluctant to visit a doctor for minor health issues and routine diagnostic visits. Opinions vary on how often a healthy man should visit their doctor. One rule of thumb is at least every three years for men under 40 years old, every other year between the ages of 40 and 50, and then annually after they have reached 50 years old. But a great deal of the decision making process should involve talking with your doctor, family history and any underlying health conditions.
A Special Note on Screening
A number of conflicting and confusing guidelines have been released by various organizations during recent years about whether or not men should be screened for prostate cancer. Legitimate questions have been raised about whether treating some men with prostate cancer carries risks that outweigh the benefits. At the same time, clear proof exists that since the PSA (Prostate Specific Antigen) test came into wide use the death rate from prostate cancer has declined significantly.
Pints for Prostates takes the position that men have the right to make informed decisions about their health care and should have access to the best available screening tools. We believe that men should be screened, know their numbers and be able to have an intelligent conversation with their doctor about their diagnosis. We want men to take charge of their health.
Pints for Prostates does not advocate for any specific form of treatment. That is a highly personal decision and depends on a great many factors. If diagnosed with prostate cancer, men need to review the options, talk with their families, consult with their doctors and speak with men who have been through similar situations. For some men, watchful waiting is the proper path. For others, there are a variety of treatment options, up to and including surgery. While the PSA test is one of the best screening tool we now have available, it does not tell men if they have prostate cancer. Current biopsies do not give men certainty as to whether the cancer is slow growing or aggressive. We are encouraged by research taking place to find more accurate tools that will help men and their doctors decide on the best possible treatment plan.
At the World Prostate Cancer Congress that took place in Melbourne, Australia, in 2013, a group of leading doctors from around the globe issued a consensus statement on prostate cancer screening that we believe offers important, intelligent and useful guidance to men on whether or not they should get tested. These are some of the best minds on the subject and are physcians that have treated thousands of men. There will likely be some that criticize this consensus statement, claiming it comes from urologists protecting their turf. But these physicians see firsthand the advantages of early detection in fighting prostate cancer and have treated men at all different stages of the disease. We have decided to print the contents of the statement because it offers an honest, realistic and thoughtful approach to prostate cancer screening that we believe is in the best interests of men facing the disease.
The Melbourne Consensus Statement on Prostate Cancer Testing
A consensus view on the early detection of prostate cancer, led by experts at the Prostate Cancer World Congress, Melbourne, 7–10th August 2013
Recent guideline statements and recommendations have led to further confusion and controversy regarding the use of Prostate Specific Antigen (PSA) testing for the early detection of prostate cancer. Despite high-level evidence for the use of PSA testing as a screening tool, and also for its role as a predictor of future risk, the U.S. Preventive Services Taskforce (USPSTF) has called for PSA testing to be abandoned completely , and many men are therefore not given the opportunity for shared decision-making. Other groups such as the American Urological Association, National Comprehensive Cancer Network, and European Association of Urology support a role for PSA screening but with somewhat conflicting recommendations. The majority of guideline statements have endorsed the role of shared decision-making for men considering PSA testing.
To address these somewhat conflicting and confusing positions, a group of leading prostate cancer experts from around the world have come together at the 2013 Prostate Cancer World Congress in Melbourne and have generated the following set of consensus statements regarding the use of PSA testing. The goal of these statements is to bring some clarity to the confusion that exists with existing guidelines, and to present reasonable and rational guidance for the early detection of prostate cancer today.
- Consensus Statement 1: For men aged 50–69, level 1 evidence demonstrates that PSA testing reduces prostate cancer-specific mortality and the incidence of metastatic prostate cancer. In the European Randomized Study of Screening for Prostate Cancer (ERSPC), screening reduced metastatic disease and prostate cancer-specific mortality by up to 30% and 21% respectively in the intent-to-treat analysis, with a greater reduction after adjustment for noncompliance and contamination[2,3]. In addition, the Goteborg randomized population-based randomized trial showed a reduction in metastatic disease and prostate cancer mortality with screening starting at age 50 . The degree of over-diagnosis and over-treatment reduces considerably with longer follow-up, such that the numbers needed to screen and numbers needed to diagnose compare very favourably with screening for breast cancer. While routine population-based screening is not recommended, healthy, well-informed men in this age group should be fully counseled about the positive and negative aspects of PSA testing to reduce their risk of metastases and death. This should be part of a shared decision-making process.
- Consensus Statement 2: Prostate cancer diagnosis must be uncoupled from prostate cancer intervention. Although screening is essential to diagnose high-risk cases within the window of curability, it is clear that many men with low-risk prostate cancer do not need aggressive treatment. Active surveillance protocols have been developed and have been shown to be a reasonable and safe option for many men with low-volume, low-risk prostate cancer [5,6]. While it is accepted that active surveillance does not address the issue of over-diagnosis, it does provide a vehicle to avoid excessive intervention. Active surveillance strategies need standardization and validation internationally to reassure patients and clinicians that this is a safe strategy.
- Consensus Statement 3: PSA testing should not be considered on its own, but rather as part of a multivariable approach to early prostate cancer detection. PSA is a weak predictor of current risk and additional variables such as digital rectal examination, prostate volume, family history, ethnicity, and risk prediction models can help to better risk stratify men, potentially reducing over-diagnosis and over-treatment of indolent prostate cancer. Prostate cancer risk calculators such as those generated from the ERSPC ROTTERDAM (www.prostatecancer-riskcalculator.com), the Prostate Cancer Prevention Trial (PCPT) (http://deb.uthscsa.edu/URORiskCalc/Pages/uroriskcalc.jsp), and from Canada (prostaterisk.ca), are useful tools to help men understand the risk of prostate cancer in these populations. Further developments in the area of biomarkers, as well as improvements in imaging will continue to improve risk stratification, with potential for reduction in over-diagnosis and over-treatment of lower risk disease.
- Consensus Statement 4: Baseline PSA testing for men in their 40s is useful for predicting the future risk of prostate cancer. Although these men were not included in the two main randomized trials, there is strong evidence that this is a group of men who may benefit from the use of PSA testing as a baseline to aid risk stratification for their likely future risk for developing prostate cancer , including clinically significant prostate cancer. Studies have shown the value of PSA testing in this cohort for predicting the increased likelihood of developing prostate cancer 25 years later for men whose baseline PSA is in the highest centiles above the median [8,9]. For example, those men with a PSA below the median could be spared regular PSA testing as their future risk of developing prostate cancer is comparatively low, whereas those with a PSA above the median are at considerably higher risk and need closer surveillance. The median PSA for men aged 40–49 ranges from 0.5–0.7 ng/ml, with the 75th percentile ranging from 0.7–0.9ng/ml. The higher above the median, the greater the risk of later developing life-threatening disease. We recommend that a baseline PSA in the 40s has value for risk stratification and this option should be discussed with men in this age group as part of a shared decision-making process.
- Consensus Statement 5: Older men in good health with over ten year life expectancy should not be denied PSA testing on the basis of their age. Men should be assessed on an individual basis rather than applying an arbitrary chronological age beyond which testing should not occur. As life expectancy improves in many countries around the world (men aged 70 in Australia have a 15 year life expectancy), a small proportion of older men may benefit from an early diagnosis of more aggressive forms of localised prostate cancer, just as it is clear that men with many competing co-morbidities and less aggressive forms of prostate cancer are unlikely to benefit irrespective of age. Likewise, a man in his 70s who has had a stable PSA at or below the median for a number of years previously is at low risk of developing a threatening prostate cancer and regular PSA screening should be discouraged.
An important goal when considering early detection of prostate cancer today, is to maintain the gains that have been made in survival over the past thirty years since the introduction of PSA testing, while minimizing the harms associated with over-diagnosis and over-treatment. This is already happening in Australia where over 40% of patients with low-risk prostate cancer are managed with surveillance or watchful waiting , and in Sweden where 59% of very low risk patients are on active surveillance. This is also reflected in current guidelines from the EAU, NCCN and other expert bodies, and in a comment from AUA Guideline author Dr Bal Carter in the BJU International.
Abandonment of PSA testing as recommended by the USPSTF, would lead to a large increase in men presenting with advanced prostate cancer and a reversal of the gains made in prostate cancer mortality over the past three decades.
However, any discussion about surveillance is predicated on having a diagnosis of early prostate cancer in the first instance. As Dr Joseph Smith editorialized in the Journal of Urology following the publication of the ERSPC and PLCO trials, “treatment or non-treatment decisions can be made once a cancer is found, but not knowing about it in the first place surely burns bridges” . A key strategy therefore is to continue to offer well-informed men the opportunity to be diagnosed early, while minimizing harms by avoiding intervention in those men at low risk of disease progression. This consensus statement provides some guidance to help achieve these goals.
A/Professor Declan G Murphy, University of Melbourne, Peter MacCallum Cancer Centre, Melbourne, Australia
Professor Tony Costello, University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
Dr Patrick C Walsh, The James Buchanan Brady Urological Institute, Johns Hopkins University, USA
Dr Thomas Ahlering, University of California, Irvine, School of Medicine, USA
Dr William C Catalona, Northwestern University Feinberg School of Medicine, USA
Professor Noel Clarke, Manchester University, The Christie Hospital, Manchester, UK
Dr Matthew Cooperberg, University of California San Francisco, Helen Diller Family Comprehensive Cancer Centre, USA
Dr David Gillatt, University of Bristol, Bristol Urological Institute, Bristol, UK
Dr Martin Gleave, University of British Columbia, The Vancouver Prostate Centre, Vancouver, Canada
Dr Stacy Loeb, New York University, USA
Dr Monique Roobol, Erasmus University Medical Centre, Rotterdam, The Netherlands
The median PSA for men aged 40–49 ranges from 0.5–0.7ng/ml. The 75th percentile ranges from 0.7–0.9ng/ml.
 Moyer VA, Force USPST. Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2012;157:120–34.
 Schroder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, et al. Prostate-cancer mortality at 11 years of follow-up. N Engl J Med. 2012;366:981–90.
 Schroder FH, Hugosson J, Carlsson S, Tammela T, Maattanen L, Auvinen A, et al. Screening for prostate cancer decreases the risk of developing metastatic disease: findings from the European Randomized Study of Screening for Prostate Cancer (ERSPC). Eur Urol. 2012;62:745–52.
 Hugosson J, Carlsson S, Aus G, Bergdahl S, Khatami A, Lodding P, et al. Mortality results from the Goteborg randomised population-based prostate-cancer screening trial. Lancet Oncol. 2010;11:725–32.
 Bul M, Zhu X, Valdagni R, Pickles T, Kakehi Y, Rannikko A, et al. Active surveillance for low-risk prostate cancer worldwide: the PRIAS study. Eur Urol. 2013;63:597–603.
 Bangma CH, Bul M, van der Kwast TH, Pickles T, Korfage IJ, Hoeks CM, et al. Active surveillance for low-risk prostate cancer. Crit Rev Oncol Hematol. 2012.
 Loeb S. Use of baseline prostate-specific antigen measurements to personalize prostate cancer screening. Eur Urol. 2012;61:875–6.
 Vickers AJ, Ulmert D, Sjoberg DD, Bennette CJ, Bjork T, Gerdtsson A, et al. Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-55 and long term risk of metastasis: case-control study. BMJ. 2013;346:f2023.
 Lilja H, Cronin AM, Dahlin A, Manjer J, Nilsson PM, Eastham JA, et al. Prediction of significant prostate cancer diagnosed 20 to 30 years later with a single measure of prostate-specific antigen at or before age 50. Cancer. 2011;117:1210–9.
 Evans SM, Millar JL, Davis ID, Murphy DG, Bolton DM, Giles GG, et al. Patterns of care for men diagnosed with prostate cancer in Victoria from 2008 to 2011. Med J Aust. 2013;198:540–5.
 Smith JA, Jr. What would you do, doctor? J Urol. 2009;182:421–2.